Abstract

This paper considers the problem of fair probabilistic binary classification with binary protected groups. The classifier assigns scores, and a practitioner predicts labels using a certain cut-off threshold based on the desired trade-off between false positives vs. false negatives. It derives these thresholds from the ROC of the classifier. The resultant classifier may be unfair to one of the two protected groups in the dataset. It is desirable that no matter what threshold the practitioner uses, the classifier should be fair to both the protected groups; that is, the L p norm between FPRs and TPRs of both the protected groups should be at most ε . We call such fairness on ROCs of both the protected attributes ε p -Equalized ROC. Given a classifier not satisfying ε 1 -Equalized ROC, we aim to design a post-processing method to transform the given (potentially unfair) classifier's output (score) to a suitable randomized yet fair classifier. That is, the resultant classifier must satisfy ε 1 -Equalized ROC. First, we introduce a threshold query model on the ROC curves for each protected group. The resulting classifier is bound to face a reduction in AUC. With the proposed query model, we provide a rigorous theoretical analysis of the minimal AUC loss to achieve ε 1 -Equalized ROC. To achieve this, we design a linear time algorithm, namely \texttt{FROC}, to transform a given classifier's output to a probabilistic classifier that satisfies ε 1 -Equalized ROC. We prove that under certain theoretical conditions, \texttt{FROC}\ achieves the theoretical optimal guarantees. We also study the performance of our \texttt{FROC}\ on multiple real-world datasets with many trained classifiers.

Abstract

This paper uses 3D stochastic geometry to analyse the coverage and meta-distribution (MD) performance of a low Earth orbit (LEO) satellite-based Internet-of-Things (IoT) network. The satellites are considered to be distributed at a fixed altitude around Earth following a Binomial point process. An IoT device broadcasts its sensed information to all the satellites with a line-of-sight within the visibility region and they act as selective decode-and-forward gateways. The ground server coherently combines the information received from multiple satellites. The analytically derived performance measures are verified through Monte Carlo simulations. The results demonstrate the impact of mega-LEO constellations on coverage and reliability, guiding 6G architecture design to improve connectivity and data offloading in smart cities and dense urban environments.

Abstract

A visual question answering (VQA) system for electrical circuit images could be useful as a quiz generator, design and verification assistant or an electrical diagnosis tool. Although there exists a vast literature on VQA, to the best of our knowledge, there is no existing work on VQA for electrical circuit images. To this end, we curate a new dataset, CircuitVQA, of 115K+ questions on 5725 electrical images with 70 circuit symbols. The dataset contains schematic as well as hand-drawn images. The questions span various categories like counting, value, junction and position based questions. To be effective, models must demonstrate skills like object detection, text recognition, spatial understanding, question intent understanding and answer generation. We experiment with multiple foundational visio-linguistic models for this task and find that a finetuned BLIP model with component descriptions as additional input provides best results. We make the code and dataset publicly available

Abstract

A system and method for implementing an experiment remotely and determining an output using a computer-vision model is provided. The system includes an image capturing device, an experiment setup, a microcontroller, a user device, and a relay unit. The microcontroller (i) receives the input of the experiment from the image capturing device,(ii) extracts one or more frames from the input data,(iii) pre-process the one or more frames to obtain a binary image,(iv) obtain a closed curve around the binary image to locate the experiment,(v) determine the coordinates of the experiment to track the experiment in each frame,(vi) determine an output of the experiment from every two consecutive frames of the one or more frames, and (vii) optimize the determined output of the experiment using a linear regression model.

Abstract

When novice engineers (fresh or recent graduates with little industry experience) join a SaaS (Software-as-a-Service) product company, they are tasked with comprehending the product, especially its behavior and dynamics. We believe that they can comprehend more effectively if they know and understand the architecture patterns used in the product. Are the current architecture pattern descriptions of high quality? Do they fit the needs of novice engineers? We evaluated the pattern descriptions of Model-View-Controller (MVC) (a popular and important architecture pattern for cloud systems) from a quality and fitment perspective and found gaps. To address these gaps, we have built a System of Systems (SoS) model of MVC that uses a transition systems vocabulary and a set-theoretic notation. In the paper, we show that this SoS model provides a rich set of information about the behavior and dynamics of the MVC components and their interactions. The model bridges the gaps in the MVC pattern description. One of the contributions of the paper is to provide criteria to evaluate the pattern descriptions for quality and fitment for novice engineers. The paper proposes that we augment the benchmark pattern description of MVC with an SoS model. The paper also demonstrates a general approach to building SoS models for architecture patterns and recommends creating a catalog of SoS models for SaaS architecture patterns. We believe such a catalog will significantly help novice engineers in comprehension and other software engineering activities.

Abstract

In literature, various time-frequency representation methods were investigated for automatic detection of voice disorders. Stockwell-Transform (S-Transform) provides good time-frequency localization; hence, it may efficiently capture the voice disorder related information from speech signal. With this motivation, we investigated different variants of S-Transform for the classification of voice disorders. This study proposed the S-Transform based cepstral coefficients for voice disorder detection and assessment. The performance of the proposed feature was compared with baseline features on SVD and HUPA databases. Compared to baseline features, proposed features performed best in terms of classification accuracy of 80.2% and 79.8% on HUPA and SVD databases, respectively for voice disorder detection task. Also, the proposed features performed better in case of assessment task. Further, the experimental results reveal that combining cepstral coefficients derived from S-Transform with baseline features improved the performance of proposed systems by 8% and 4% for detection and assessment tasks, respectively which highlights complementary nature of the explored features. We also analysed the effectiveness of S-Transform based spectral representation in capturing the acoustic characteristics for various voice qualities like breathiness, harshness, creakiness, and falsetto phonations. This representation was also compared with other time-frequency based methods such as STFT, ZTW and SFF. It was observed that S-Transform effectively captures the acoustic variations associated with different voice qualities compared to other baseline methods, which may be due to better spectro-temporal resolution offered by the S-Transform.

Abstract

The IEEE International Conference on Software Architecture (ICSA) is the premier gathering of practitioners and researchers interested in software architecture, component-based software engineering, and quality aspects of complex software systems. The 21st IEEE International Conference on Software Architecture (ICSA 2024) continued the tradition of a working conference, where attendees met and where software architects were able to explain the challenges they face and try to influence the future of the field. Interactive working sessions were the place where researchers met practitioners to identify opportunities to shape the future of our field.

Abstract

Leishmania donovani causes a neglected tropical disease called visceral leishmaniasis. Additionally, leishmaniasis also manifests opportunistically, under conditions of immune compromise. The continued non-availability of effectively curative interventions (drugs or vaccines) against this disease necessitates a deeper knowledge of Leishmania biology in order to evolve novel strategies against the disease. We have used a meta-analysis approach to analyse Leishmania’s composite genetic network rather than investigating individual candidate genes. We performed Weighted Gene Co-expression Network Analysis (WGCNA) on publicly available Leishmania donovani transcriptome data to identify co-regulatory genetic modules. This clustering of Leishmania donovani transcriptomes revealed that genes fall in 30 distinct co-regulated modules with 32 to 3012 genes. In order to analyse the distribution of genes in Leishmania gene modules, we queried the enrichment or depletion of various annotation-qualifiers in the modules. We observed that several modules are specifically and individually enriched or depleted for annotation qualifiers derived from GO-annotation and KEGG-pathways and are differentially associated with life-phases and experimental conditions. Additionally, modules are also enriched or depleted for sequence based genetic features such as chromosomal location, location on co-transcriptional segment, rank of transcript from initiation of transcription, skewed usage of known RNA Binding Protein motifs. Classification of uncharacterized transcripts into co-regulatory modules provides insights in their probable characteristics, aiding future empirical investigation. Strikingly, two of the modules have reciprocal features including individual associations with logarithmic or stationary growth phases of Leishmania, two important life-phases that simulate the vector-dwelling pro-cyclic and the pre-infective meta-cyclic forms. Collectively, our analyses of Leishmania co-regulated gene modules is suggestive of additional regulatory modes over the mere differential mRNA stabilization.

Abstract

Cancer metabolism is characterized by significant heterogeneity, presenting challenges for treatment efficacy and patient outcomes. Understanding this heterogeneity and its regulatory mechanisms at single-cell resolution is crucial for developing personalized therapeutic strategies. In this study, we employed a single-cell network approach to characterize malignant heterogeneity in gynecologic and breast cancers, focusing on the transcriptional regulatory mechanisms driving metabolic alterations. By leveraging single-cell RNA sequencing (scRNA-seq) data, we assessed the metabolic pathway activities and inferred cancer-specific protein-protein interactomes (PPI) and gene regulatory networks (GRNs). We explored the crosstalk between these networks to identify key alterations in metabolic regulation. Clustering cells by metabolic pathways revealed tumor heterogeneity across cancers, highlighting variations in oxidative phosphorylation, glycolysis, cholesterol, fatty acid, hormone, amino acid, and redox metabolism. Our analysis identified metabolic modules associated with these pathways, along with their key transcriptional regulators. Notably, transcription factors related to ER stress, immune response, and cell proliferation, along with hypoxia-inducible factor and sterol regulatory element-binding proteins were found to drive metabolic reprogramming. These findings provide new insights into the complex interplay between metabolic rewiring and transcriptional regulation in gynecologic and breast cancers, offering potential avenues for targeted therapeutic strategies in precision oncology. Furthermore, this pipeline for dissecting coregulatory metabolic networks can be broadly applied to decipher metabolic regulation in any disease at single-cell resolution.

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by challenges in social communication, repetitive behaviors, and restricted interests. Recent research has emphasized the importance of metabolic dysfunctions in the pathophysiology of ASD. This study investigates metabolic alterations associated with ASD by analyzing transcriptomic data obtained from the prefrontal cortex (bulk tissue and single-nucleus) and data from peripheral blood mononuclear cells (PBMC). We assessed the metabolic activity of each patient based on gene expression profiles, revealing significant downregulation of vital metabolic pathways, including glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation, indicative of hypometabolism. Our analysis also highlighted dysregulation in lipid, vitamin, amino acid, and heme metabolism, which may contribute to the neurodevelopmental delays associated with ASD. Cell-specific metabolic activities in the ASD brain showed altered pathways in astrocytes, oligodendrocytes, excitatory neurons, and interneurons. Furthermore, we identified critical metabolic pathways and genes from PBMC gene expression data that distinguish ASD patients from typically developing individuals. Our findings demonstrate a consistent pattern of metabolic dysfunction across brain and blood samples. This research provides a comprehensive understanding of metabolic alterations in ASD, paving the way for exploring potential therapeutic strategies targeting metabolic dysregulation.