Abstract

We show that there exists endotactic and strongly endotactic dynamical systems that are not weakly reversible and possess infinitely many steady states. We provide a few examples in two dimensions and an example in three dimensions that satisfy this property. In addition, we prove for some of these systems that there exist no weakly reversible mass-action systems that are dynamically equivalent to mass-action systems generated by these networks.

Abstract

Risk assessment is vital for comprehending and managing river water quality control. By ensuring a systematic approach for evaluating potential risks, it encourages the adoption of efficient management strategies, the use of informed decision-making, and maintaining of river ecosystems. An effective framework is developed by integrating the empirical based approach with Gumbel-Copula function to estimate the river water quality risk under high water temperatures and low flow rates. Based on Akaike Information Criterion (AIC) among Copula based Gumbel, Gaussian, t, and Clay-ton functions, the Gumbel-Copula function was utilized in the study. The percentiles ranging from 5 to 95 with 5 percentile interval of Stream Flows (SF) and reverse order percentiles of Water Temperatures (WT) are employed in the estimation of risk of river water quality. The current risk quantification approach was implemented using observed datasets on Yamuna (2000 to 2015) and Bhadra (2006 to 2017) river systems. The results reveal that at 50 percentile (SF=380 m3/s and WT=27.38 ℃) the join risk is about 75.29% for Yamuna River and similarly for Bhadra river the risk is about 77.62% (SF=7.20 m3/s and WT=25 ℃).

Abstract

Proof-of-Stake(PoS) based blockchain protocols have gained popularity due to their higher throughput and low carbon footprint when compared with Proof-of-Work blockchain protocols. The two major parts of blockchain protocols are the selection of the next block proposer and the selection of the longest chain. In PoS the block publishers are selected based on their relative stake. However, PoS-based blockchain protocols may face vulnerability against Fully Adaptive Corruptions. This paper proposes a novel PoS-based blockchain protocol, QuickSync, to achieve security against Fully Adaptive Corruptions while improving performance. Towards this, we propose a metric for each block: block power. We compute the chain power of a chain as the sum of block powers of all the blocks comprising the chain. The chain selection rule selects the chain with the highest chain power as the valid chain. Since the block proposer is not selected upfront, this scheme is resilient to fully adaptive corruptions, which we also show formally. We also ensure that our block power mechanism is resistant to Sybil attacks. We prove the security of QuickSync by showing that it satisfies the common prefix, chain growth, and chain quality properties. Our analysis demonstrates that QuickSync performs better than Bitcoin by order of magnitude on both transactions per second and time to finality.

Abstract

Computational drug discovery is intrinsically interdisciplinary and has to deal with the multifarious factors which are often dependent on the type of disease. Molecular Property Diagnostic Suite (MPDS) is a Galaxy based web portal which was conceived and developed as a disease specific web portal, originally developed for tuberculosis (MPDSTB). As specific computational tools are often required for a given disease, developing a disease specific web portal is highly desirable. This paper emphasises on the development of the customised web portal for COVID-19 infection and is referred to as MPDSCOVID-19. Expectedly, the MPDS suites of programs have modules which are essentially independent of a given disease, whereas some modules are specific to a particular disease. In the MPDSCOVID-19 portal, there are modules which are specific to COVID-19, and these are clubbed in SARS-COV-2 disease library. Further, the new additions and/or significant improvements were made to the disease independent modules, besides the addition of tools from galaxy toolshed. This manuscript provides a latest update on the disease independent modules of MPDS after almost 6 years, as well as provide the contemporary information and tool-shed necessary to engage in the drug discovery research of COVID-19. The disease independent modules include file format converter and descriptor calculation under the data processing module; QSAR, pharmacophore, scaffold analysis, active site analysis, docking, screening, drug repurposing tool, virtual screening, visualisation, sequence alignment, phylogenetic analysis under the data analysis module; and various machine learning packages, algorithms and in-house developed machine learning antiviral prediction model are available. The MPDS suite of programs are expected to bring a paradigm shift in computational drug discovery, especially in the academic community, guided through a transparent and open innovation approach. The MPDSCOVID-19 can be accessed at http://mpds.neist.res.in:8085.

Abstract

Gauging the knowledge of Pretrained Language Models (PLMs) about facts in niche domains is an important step towards making them better in those domains. In this paper, we aim at evaluating multiple PLMs for their knowledge about world Geography. We contribute (i) a sufficiently sized dataset of masked Geography sentences to probe PLMs on masked token prediction and generation tasks, (ii) benchmark the performance of multiple PLMs on the dataset. We also provide a detailed analysis of the performance of the PLMs on different Geography facts.

Abstract

The emergence of smart grid technology has opened the door for wide-scale automation in decision-making. A distribution company, an integral part of a smart grid system, has to procure electricity from the wholesale market and then sell it to customers in the retail market by publishing attractive tariff contracts. It can deploy autonomous agents to make decisions on its behalf. In this work, we describe the tariff contracts generation strategy of one such autonomous agent, which is based on a Contextual Multi-armed Bandit (ConMAB) based learning technique to generate tariff contracts for various types of customers in the retail market of smart grids. We particularly utilize the Exponential-weight algorithm for Exploration and Exploitation (EXP-3) for ConMAB-based learning. We call our proposed strategy GenerateTariffs-EXP3. Our previous work shows that maintaining an appropriate market share in the retail market yields high net revenue. Thus, we first present a game-theoretic analysis that determines an optimal level of market share. Then we train our proposed strategy to achieve and maintain the suggested level of market share by adapting to the market situation and revising the tariff contracts periodically. We validate our proposed strategy in PowerTAC, a close-to real-world smart grid simulator, and showcase that it is able to maintain the suggested market share.

Abstract

The Multi-Object Navigation (MultiON) task requires a robot to localize an instance (each) of multiple object classes. It is a fundamental task for an assistive robot in a home or a factory. Existing methods for MultiON have viewed this as a direct extension of Object Navigation (ON), the task of localising an instance of one object class, and are pre-sequenced, i.e., the sequence in which the object classes are to be explored is provided in advance. This is a strong limitation in practical applications characterized by dynamic changes. This paper describes a deep reinforcement learning framework for sequence-agnostic MultiON based on an actor-critic architecture and a suitable reward specification. Our framework leverages past experiences and seeks to reward progress toward individual as well as multiple target object classes. We use photo-realistic scenes from the Gibson benchmark dataset in the AI Habitat 3D simulation environment to experimentally show that our method performs better than a pre-sequenced approach and a state of the art ON method extended to MultiON.

Abstract

Preserving cultural heritage is of paramount importance. In the domain of art restoration, developing a computer vision model capable of effectively restoring deteriorated images of art pieces was difficult but now we have good computer vision state-of-art. Traditional restoration methods are often time-consuming and require extensive expertise. The aim of this work is to design an automated solution based on computer vision models that can enhance and reconstruct degraded artworks, improving their visual quality while preserving their original characteristics and artifacts. The model should handle a diverse range of deterioration types, including but not limited to noise, blur, scratches, fading, and other common forms of degradation. We adapt the current state-of-art for the image super resolution based on Diffusion Model (DM) and fine-tune it for Image art restoration. Our result show that the instead of fine-tunning multiple different model for different kind of degradation, fine- tunning one super-resolution. We train it on the multiple datasets to make it robust.

Abstract

Speech systems are sensitive to accent variations. This is a challenge in India, which has numerous languages but few linguistic studies on pronunciation variation. The growing number of L2 English speakers reinforces the need to study accents and L1-L2 interactions. We investigate Indian English (IE) accents and report our observations on regional and shared features. Specifically, we observe phonemic variations and phonotactics in speakers’ native languages and apply this to their English pronunciations. We demonstrate the influence of 18 Indian languages on IE by comparing native language features with IE pronunciations obtained from literature studies and phonetically annotated speech. Hence, we validate Indian language influences on IE by justifying pronunciation rules from the perspective of Indian language phonology. We obtain a comprehensive description of generalised and region-specific IE characteristics, which facilitates accent adaptation of existing speech systems.

Abstract

Cocaine use disorder (CUD) is described as a compulsive urge to seek and consume cocaine despite the inimical consequences. MRI studies from different modalities have shown that CUD patients exhibit structural and/or functional connectivity pathology among several brain regions. Nevertheless, both connectivities are commonly studied and analyzed separately, which may potentially obscure its relationship between them, and with the clinical pathology. Here, we compare and contrast structural and functional brain networks in CUD patients and healthy controls (HC) using multimodal fusion. The sample consisted of 63 (8 females) CUD patients and 42 (9 females) healthy controls (HC), recruited as part of the SUDMEX CONN database. For this, we computed a battery of graph-based measures from multi-shell diffusion-weighted imaging and resting state fc-fMRI to quantify local and global connectivity. Then we used multimodal canonical component analysis plus joint independent component analysis (mCCA+jICA) to compare between techniques, and evaluate group differences and its association with clinical alteration. Unimodal results showed a striatal decrease in the participation coefficient, but applied supervised data fusion revealed other regions with cocaine-related alterations in joint functional communication. When performing multimodal fusion analysis, we observed a higher centrality of the interrelationship and a lower participation coefficient in patients with CUD. In contrast to the unimodal approach, the multimodal fusion method was able to reveal latent information about brain regions involved in impairment due to cocaine abuse. The present results could help in understanding the pathology of CUD in order to develop better pre-treatment/post-treatment intervention designs