Abstract

The thermodynamics of the hydrophobic effect, as measured primarily through the temperature dependence of solubility, is reviewed, and then a class of models that incorporate the basic mechanism of hydrophobicity is described. These models predict a quantitative relation between the free energy of hydrophobic hydration and the strength of the solvent-mediated attraction between pairs of solute molecules. It is remarked that the free energy of attraction being just of the order of the thermal energy kT may be important for the effective operation of the hydrophobic effect in proteins. Deviations from pairwise additivity of hydrophobic forces are also briefly discussed.

Abstract

The liver plays a vital role in maintaining whole-body metabolic homeostasis, compound detoxification and has the unique ability to regenerate itself post-injury. Ageing leads to functional impairment of the liver and predisposes the liver to non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Mapping the molecular changes of the liver with ageing may help to understand the crosstalk of ageing with different liver diseases. A systems-level analysis of the ageing-induced liver changes and its crosstalk with liver-associated conditions is lacking. In the present study, we performed network-level analyses of the ageing liver using mouse transcriptomic data and a protein–protein interaction (PPI) network. A sample-wise analysis using network entropy measure was performed, which showed an increasing trend with ageing and helped to identify ageing genes based on local entropy changes. To

Abstract

Identification of cancer subtypes based on molecular knowledge is crucial for improving the patient diagnosis, prognosis, and treatment. In this work, we integrated copy number variations (CNVs) and transcriptomic data of Kidney Papillary Renal Cell Carcinoma (KIRP) using a network diffusion strategy to stratify cancers into clinically and biologically relevant subtypes. We constructed GeneNet, a KIRP specific gene expression network from RNA-seq data. The copy number variation data was projected onto GeneNet and propagated on the network for clustering. We identified robust subtypes that are biologically informative and significantly associated with patient survival, tumor stage and clinical subtypes of KIRP. We performed a Singular Value Decomposition (SVD) analysis of KIRP subtypes, which revealed the genes/silent players related to poor survival. A differential gene expression analysis between

Abstract

The leading order production of an SM singlet-like scalar has primarily been realized through the gluon fusion process by mixing with the SU(2)_L scalar doublet of the model. The dominant part of the physical state, i.e., the singlet component, does not have any role in its direct production. Focusing on such a state with a mass smaller than the SM-like Higgs scalar, we calculate the dominant next-to-leading (NLO) order corrections to its production cross-section. With these improved cross-sections, the present and future LHC limits may become somewhat more stringent

Abstract

Systems of differential equations with polynomial right-hand sides are very common in applications. In particular, when restricted to the positive orthant, they appear naturally (according to the law of mass-action kinetics) in ecology, population dynamics, as models of biochemical interaction networks, and models of the spread of infectious diseases. On the other hand, their mathematical analysis is very challenging in general; in particular, it is very difficult to answer questions about the long-term dynamics of the variables (species) in the model, such as questions about persistence and extinction. Even if we restrict our attention to mass-action systems, these questions still remain challenging. On the other hand, if a polynomial dynamical system has a weakly reversible single linkage class (WR1 ) realization, then its long-term dynamics is known to be remarkably robust: all the variables are persistent (i.e., no species goes extinct), irrespective of the values of the parameters in the model. Here we describe an algorithm for finding WR1 realizations of polynomial dynamical systems, whenever such realizations exist.

Abstract

Understanding the riverine thermal regimes is challenging due to sparse spatiotemporal data of river water temperatures (RWTs). The development of systematic models combined with machine learning models under data‐limited context has not been intensively studied for the prediction of RWT. The present study developed hybrid models using long short‐term memory (LSTM), integrated with (a) k‐nearest neighbor (k‐NN) bootstrap resampling algorithms (kNN‐LSTM) to address the data limitations of RWT prediction and (b) discrete wavelet transform (WT) approach (WT‐LSTM) to address the time–frequency localized features of RWT prediction. The study assessed the climate change impacts on RWT using an ensemble of National Aeronautics Space Administration Earth Exchange Global Daily Downscaled Projections of air temperature with Representative Concentration Pathway scenarios 4.5 and 8.5 for

Abstract

In Himalayas, the high-elevational mountains have warmed more rapidly in recent decades than other areas of the globe. Himalayan timberline is climate dependent and sensitive to changes, thus can provide biological proof of global warming. The present analysis changes in timberline elevations over four decades and corresponding climatic parameters (temperature and precipitation) in the Western Himalayan region (Himachal Pradesh). Landsat-2 Multispectral Scanner (MSS) and Landsat-8 were used to evaluate the long-term (1976–2015) timberline dynamics. The climate data APHRODITE was used to calculate the annual mean temperature and annual precipitation along the spatially distinct timberline locations. The mean elevation of timberline position has shifted vertically 145 m with a rate of ~37 m per decade (@ 3.7 m per year) over the past four decades, however majority of timberline remained

Abstract

Modeling Uncertainty Quantification of NDVI of Agricultural Fields through Bayesian Linear Regression in Time Series Prediction

Abstract

Software practitioners use various requirement elicitation methods to produce a well-defined product. These methods impact the software product’s eventual traits and target a particular audience segment. Virtual Reality(VR) products are no different from this influence. With the notable rise in product offerings across various domains, VR has become an essential technology for the future. Nevertheless, the type of methods practiced for requirement elicitation still has not been thoroughly studied. This paper presents a mapping study on requirement elicitation methods practiced by VR practitioners in academia and industry. We consolidated our observations based on their popularity in the practitioner community. Further, we present our insights on the necessary and sufficient conditions to conduct VR requirement elicitation using the identified methods to benefit the VR practitioner community.

Abstract

One of the key challenges for a novice engineer in a product company is to comprehend the product sufficiently and quickly. It can take anywhere from six months to several years for them to attain mastery but they need to start delivering results much before. SaaS (Software-as-a-Service) products have sophisticated system architecture which adds to the time and effort of understanding them. On the other hand, time available to new hires for product understanding continues to be short and getting shorter, given the pressure to deliver more in less time. Constructivist theory views learning as a personal process in which the learner constructs new knowledge for themselves. Building and refining a mental model is the key way in which they learn, similar to how the brain operates. This paper presents an approach to improve system comprehension process by using a system model that a) acts as a transitional object to aid and refine the mental model of the learner, and b) captures the current understanding of the dynamics of the software system in a way that can be reasoned with and simulated. We have adapted discrete systems modeling techniques and used a transition system as a lightweight modeling language. Such a model can be used by novice engineers during their product ramp-up phase to build a model of the software system that captures their knowledge of the system and aid their mental model. The paper also presents a learning approach in which the learners create and refine these models iteratively using the available and newly uncovered knowledge about the software system. We hypothesize that by leveraging this modeling