Abstract

Computational modeling of the spontaneous dynamics over the whole brain provides critical insight into the spatiotemporal organization of brain dynamics at multiple resolutions and their alteration to changes in brain structure (e.g. in diseased states, aging, across individuals). Recent experimental evidence further suggests that the adverse effect of lesions is visible on spontaneous dynamics characterized by changes in resting state functional connectivity and its graph theoretical properties (e.g. modularity). These changes originate from altered neural dynamics in individual brain areas that are otherwise poised towards a homeostatic equilibrium to maintain a stable excitatory and inhibitory activity. In this work, we employ a homeostatic inhibitory mechanism, balancing excitation and inhibition in the local brain areas of the entire cortex under neurological impairments like lesions to understand global functional …

Abstract

Stroke is the leading cause of severe chronic disability and the second cause of death worldwide with 15 million new cases and 50 million stroke survivors. The post stroke chronic disability may be ameliorated with early neuro rehabilitation where non-invasive brain stimulation (NIBS) techniques can be used as an adjuvant treatment to hasten the effects. However, the heterogeneity in the lesioned brain will require individualized NIBS intervention where innovative neuroimaging technologies of portable electroencephalography (EEG) and functional-near-infrared spectroscopy (fNIRS) can be leveraged for Brain State Dependent Electrotherapy (BSDE). In this hypothesis and theory article, we propose a computational approach based on excitation-inhibition (E-I) balance hypothesis to objectively quantify the post stroke individual brain state using online fNIRS-EEG joint imaging. One of the key events that occurs following Stroke is the imbalance in local excitation-inhibition (that is the ratio of Glutamate/GABA) which may be targeted with NIBS using a computational pipeline that includes individual “forward models” to predict current flow patterns through the lesioned brain or brain target region. The current flow will polarize the neurons which can be captured with excitation-inhibition based brain models. Furthermore, E-I balance hypothesis can be used to find the consequences of cellular polarization on neuronal information processing which can then be implicated in changes in function. We first review evidence that shows how this local imbalance between excitation-inhibition leading to functional

Abstract

An ElectroCardiogram (ECG) inter-patient heartbeat time series classification method by a hierarchical system of based on support vector machine and Decision rule, using full heart-beat time series by alignment of R-peaks of all beats, is proposed. PQRST Time series of heart-beats having converted into equal length series by alignment of R-peaks of all heart-beats based on R-peak of largest length PQRST series in the data and by padding zeroes to the smaller length series on either side, was used in this experimentation. The main objective of this paper is to identify the abnormalities in ECG heart beats based on AAMI Categorization. Experiments were conducted on ECG data of 44 patients obtained from MIT-BIH Arrhythmia database. Results were compared with existing methods such as weighted support vector machine (SVM), hierarchical SVM and weighted linear discriminant analysis (LDA). Comparative …

Abstract

The capacity to sequence information is central to human performance. Sequencing ability forms the foundation stone for higher order cognition related to language and goal-directed planning. Information related to the order of items, their timing, chunking and hierarchical organization are important aspects in sequencing. Past research on sequencing has emphasized two distinct and independent dichotomies: implicit versus explicit and goal-directed versus habits. We propose a theoretical framework unifying these two streams. Our proposal relies on brain's ability to implicitly extract statistical regularities from the stream of stimuli and with attentional engagement organizing sequences explicitly and hierarchically. Similarly, sequences that need to be assembled purposively to accomplish a goal require engagement of attentional processes. With repetition, these goal-directed plans become habits with concomitant disengagement of attention. Thus attention and awareness play a crucial role in the implicit-to-explicit transition as well as in how goal-directed plans become automatic habits. Cortico-subcortical loops ─ basal ganglia-frontal cortex and hippocampus-frontal cortex loops ─ mediate the transition process. We show how the computational principles of model-free and model-based learning paradigms, along with a pivotal role for attention and awareness, offer a unifying framework for these two dichotomies. Based on this framework, we make testable predictions related to the potential influence of response-to-stimulus interval (RSI) on developing awareness in implicit learning tasks.

Abstract

Early detection of cardiovascular diseases can prevent the premature deaths caused by abnormal heartbeat problems. Application of unsupervised classification by Extreme learning machine is addressed for ElectroCardiogram (ECG) heart-beat time series clustering by a hybrid of Extreme learning machine and Decision rule using full heart-beat time series by alignment of R-peaks of all beats is proposed in this work. PQRST Time series of heart-beats having converted into equal length series by alignment of R-peaks of all heart-beats based on R-peak of largest length PQRST series in the data and by padding zeroes to the smaller length series on either side, was used in this experimentation. The main objective of this paper is to identify the abnormalities in ECG heart beats based on AAMI Categorization. Because of the large patient specific characteristics in ECG heartbeat morphology across individuals, the …

Abstract

Purpose: To model the modifiable risk factors by using the logistic regression (LR) and artificial neural network (ANN) models for prediction of progression of Age-related Macular Degeneration (AMD) and cross-validate these models for their predictive accuracies in a population in South India. Methods: The data (N= 3,723) were analyzed from Andhra Pradesh Eye Disease Study (APEDS) on participants aged≥ 40 years. Sub-population data from this sample were drawn by using Random under Sampling (RUS)(n= 213) and combination of RUS and Random over Sampling (ROS)(n= 1420) techniques. The modifiable and non-modifiable risk factors which were elicited as part of the study were used to derive the LR based risk score models and the model fit was assessed using bootstrap method for internal validity. The ANN model was built for three sets of data using the multi-layer feed-forward back propagation …

Abstract

Extreme learning machine (ELM) as a new learning approach has shown its good generalization performance in regression and classification applications. Clustering analysis is an important tool to explore the structure of data and has been employed in many disciplines and applications. In this paper, we present a method that builds on ELM projection of input data into a high-dimensional feature space and followed by unsupervised clustering using artificial bee colony (ABC) algorithm. While ELM projection facilitates separability of clusters, a metaheuristic technique such as ABC algorithm overcomes problems of dependence on initialization of cluster centers and convergence to local minima suffered by conventional algorithms such as K-means. The proposed ELM-ABC algorithm is tested on 12 benchmark data sets. The experimental results show that the ELM-ABC algorithm can effectively improve the …

Abstract

Perception of temporal duration is subjective and is influenced by factors such as attention and context. For example, unexpected or emotional events are often experienced as if time subjectively expands, suggesting that the amount of information processed in a unit of time can be increased. Time dilation effects have been measured with an oddball paradigm in which an infrequent stimulus is perceived to last longer than standard stimuli in the rest of the sequence. Likewise, time compression for the oddball occurs when the duration of the standard items is relatively brief. Here, we investigated whether the amount of information processing changes when time is perceived as distorted. On each trial, an oddball stimulus of varying numerosity (1–14 items) and duration was presented along with standard items that were either short (70 ms) or long (1050 ms). Observers were instructed to count the number of dots within the oddball stimulus and to judge its relative duration with respect to the standards on that trial. Consistent with previous results, oddballs were reliably perceived as temporally distorted: expanded for longer standard stimuli blocks and compressed for shorter standards. The occurrence of these distortions of time perception correlated with perceptual processing; i.e. enumeration accuracy increased when time was perceived as expanded and decreased with temporal compression. These results suggest that subjective time distortions are not epiphenomenal, but reflect real changes in sensory processing. Such short-term plasticity in information processing rate could be evolutionarily advantageous in optimizing perception and action …

Abstract

This study reports dynamic functional network connectivity (dFNC) analysis on time courses of putative empathy networks—cognitive, emotional, and motor—and the default mode network (DMN) identified from independent components (ICs) derived by the group independent component analysis (ICA) method. The functional magnetic resonance imaging (fMRI) data were collected from 15 subjects watching movies of three genres, an animation (S1), Indian Hindi (S2), and a Hollywood English (S3) movie. The hypothesis of the study is that empathic engagement in a movie narrative would modulate the activation with the DMN. The clippings were individually rated for emotional expressions, context, and empathy self-response by the fMRI subjects post scanning and by 40 participants in an independent survey who rated at four time intervals in each clipping. The analysis illustrates the following: (a) the ICA method

Abstract

Promoters are DNA sequences containing regulatory elements required to guide and modulate the transcription initiation of the gene. Predicting promoter sequences in genomic sequences is a significant task in genome annotation and understanding transcriptional regulation. In the past decade many methods with many feature extraction schemes have been proposed for the prediction of eukaryotic and prokaryotic promoters. Still there is great need for more accurate and faster methods. In this paper we employed extreme learning machine algorithm (ELM), for promoter prediction in DNA sequences of H. sapiens, D. melanogaster, A. thaliana, C. elegans and E. coli. We extracted dinucleotide and CpG island features, and achieved accuracy above 90 % for all the five species. Performance is compared with the feed forward back propagation algorithm (BP) and support vector machines (SVM) and the …