Abstract

In recent years, Voice over Internet Protocol (VoIP) has gained more and more popularity as an application of the Internet technology. For various IP applications including VoIP, the topic of Session Initiation Protocol (SIP) has attracted major concern from researchers. SIP is an advanced signaling protocol operating on Internet Telephony. SIP uses digest authentication protocols such as Simple Mail Transport Protocol (SMTP) and HyperText Transport Protocol (HTTP). When a user seeks SIP services, authentication plays an important role in providing secure access to the server only to the authorized access seekers. Being an insecure-channel-based protocol, a SIP authentication protocol is susceptible to adversarial threats. Therefore, security is a big concern in SIP authentication mechanisms. This paper reveals the security vulnerabilities of two recently proposed SIP authentication schemes for VoIP, Irshad et al.’s scheme [Multimed. Tools. Appl. doi:10.1007/s11042-013- 1807-z] and Arshad and Nikooghadam’s scheme [Multimed. Tools. Appl. DOI 10.1007/ s11042-014-2282-x], the later scheme is based on the former scheme. Irshad et al.’s scheme suffers from password guessing, user impersonation and server spoofing attacks. Arshad and Nikooghadam’s scheme can be threatened with server spoofing and stolen verifier attack. None of these two schemes achieve mutual authentication. It also fails to follow the single round-trip authentication design of Irshad et al.’s scheme. To overcome these weaknesses, we propose a provable secure single round-trip SIP authentication scheme for VoIP using smart card. We formally prove the security of the scheme in random oracle and demonstrate through discussion its resistance to various attacks. The comparative analysis shows that the proposed SIP authentication scheme offers superior performance with a little extra computational cost.

Abstract

Recently, in 2014, He and Wang proposed a robust and efficient multi-server authentication scheme using biometrics-based smart card and elliptic curve cryptography (ECC). In this paper, we first analyze He-Wang's scheme and show that their scheme is vulnerable to a known session-specific temporary information attack and impersonation attack. In addition, we show that their scheme does not provide strong user's anonymity. Furthermore, He-Wang's scheme cannot provide the user revocation facility when the smart card is lost/stolen or user's authentication parameter is revealed. Apart from these, He-Wang's scheme has some design flaws, such as wrong password login and its consequences, and wrong password update during password change phase. We then propose a new secure multi-server authentication protocol using biometric-based smart card and ECC with more security functionalities. Using the Burrows-Abadi-Needham logic, we show that our scheme provides secure authentication. In addition, we simulate our scheme for the formal security verification using the widely accepted and used automated validation of Internet security protocols and applications tool, and show that our scheme is secure against passive and active attacks. Our scheme provides high security along with low communication cost, computational cost, and variety of security features. As a result, our scheme is very suitable for battery-limited mobile devices as compared with He-Wang's scheme.

Abstract

Traditional association rule mining based on the support–confidence framework provides the objective measure of the rules that are of interest to users. However, it does not reflect the semantic measure among the items. The semantic measure of an itemset is characterized with utility values that are typically associated with transaction items, where a user will be interested to an itemset only if it satisfies a given utility constraint. In this paper, we first define the problem of finding association rules using utility-confidence framework, which is a generalization of the amount-confidence measure. Using this semantic concept of rules, we then propose a compressed representation for association rules having minimal antecedent and maximal consequent. This representation is generated with the help of high utility closed itemsets (HUCI) and their generators. We propose the algorithms to generate the utility based non-redundant association rules and methods for reconstructing all association rules. Furthermore, we describe the algorithms which generate high utility itemsets (HUI) and high utility closed itemsets with their generators. These proposed algorithms are implemented using both synthetic and real datasets. The results demonstrate better efficiency and effectiveness of the proposed HUCI-Miner algorithm compared to other well-known existing algorithms. In addition, the experimental results show better quality in the compressed representation of the entire rule set under the considered framework.

Abstract

Structural bioinformatics of RNA has evolved mainly in response to the rapidly accumulating evidence that non-(protein)-coding RNAs (ncRNAs) play critical roles in gene regulation and development. The structures and functions of most ncRNAs are however still unknown. Most of the available RNA structural databases rely heavily on known 3D structures, and contextually correlate base pairing geometry with actual 3D RNA structures. None of the databases provide any direct information about stabilization energies. However, the intrinsic interaction energies of constituent base pairs can provide significant insights into their roles in the overall dynamics of RNA motifs and structures. Quantum mechanical (QM) computations provide the only approach toward their accurate quantification and characterization. ‘RNA Base Pair Count, Geometry and Stability’ ( http://bioinf.iiit.ac.in/RNABPCOGEST …

Abstract

The roles of protonated nucleobases in stabilizing different structural motifs and in facilitating catalytic functions of RNA are well known. Among different polar sites of all the nucleobases, N7 of guanine has the highest protonation propensity at physiological pH. However, unlike other easily protonable sites such as N1 and N3 of adenine or N3 of cytosine, N7 protonation of guanine does not lead to the stabilization of base pairs involving its protonated Hoogsteen edge. It also does not facilitate its participation in any acid–base catalysis process. To explore the possible roles of N7 protonated guanine, we have studied its base pairing potentials involving WatsonCrick and sugar edges, which undergo major charge redistribution upon N7 protonation. We have carried out quantum chemical geometry optimization at the M05-2X/6-311G+(2d,2p) level, followed by interaction energy calculation at the MP2/aug-cc-pVDZ

Abstract

The current study evaluates the growing stock, biomass and carbon content of Andhra Pradesh state’s forest (India) along with its current status of forest degradation and loss. For this purpose, the study used the growing stock data collected by state forest department in 2010 for the calculation of biomass and carbon storage using the standard conversion and expansion factors given by IPCC. The analysis shows low biomass and carbon values for the state’s forest in comparison to the mean values recorded in different studies made for Andhra Pradesh. It is also observed to be lower when compared with the average carbon and biomass for Indian forests. Overall, the analysis showed degradation and loss of forest in the state, coupled with reduction in biomass and carbon sink.

Abstract

There has been a constant demand for the development of non-invasive, sensitive glucose sensor system that offers fast and real-time electronic readout of blood glucose levels. In this article, we propose a new system for detecting blood glucose levels by estimating the concentration of acetone in the exhaled breath. A TGS822 tin oxide (SnO2) sensor has been used to detect the concentration of acetone in the exhaled air. Acetone in exhaled breath showed a correlation with the blood glucose levels. Effects of pressure, temperature and humidity have been considered. Artificial Neural Network (ANN) has been used to extract features from the output waveform of the sensors. The system has been trained and tested with patient data in the blood glucose ranges from 80 mg/dl to 180 mg/dl. Using the proposed system, the blood glucose concentration has been estimated within an error limit of±7.5 mg/dl.

Abstract

Herein, the conventional and unconventional hydrogen bonding potential of adenine in APA for double zipper helical assembly of deoxyoligonucleotides is demonstrated under ambient conditions. The quantum mechanical calculations supported the formation of hybrid DNA ensembles.

Abstract

A new class of dendrimers, the poly(propyl ether imine) (PETIM) dendrimer, has been shown to be a novel hyperbranched polymer having potential applications as a drug delivery vehicle. Structure and dynamics of the amine terminated PETIM dendrimer and their changes with respect to the dendrimer generation are poorly understood. Since most drugs are hydrophobic in nature, the extent of hydrophobicity of the dendrimer core is related to its drug encapsulation and retention efficacy. In this study, we carry out fully atomistic molecular dynamics (MD) simulations to characterize the structure of PETIM (G2–G6) dendrimers in salt solution as a function of dendrimer generation at different protonation levels. Structural properties such as radius of gyration (Rg), radial density distribution, aspect ratio, and asphericity are calculated. In order to assess the hydrophilicity of the dendrimer, we compute the number of bound …

Abstract

Silent information regulator 2 (Sir2), the founding member of the conserved sirtuin family of NAD+-dependent histone deacetylase, regulates several physiological processes including genome stability, gene silencing, metabolism and life span in yeast. Within the nucleus, Sir2 is associated with telomere clusters in the nuclear periphery and rDNA in the nucleolus and regulates gene silencing at these genomic sites. How distribution of Sir2 between telomere and rDNA is regulated is not known. Here we show that Sir2 is sumoylated and this modification modulates the intra-nuclear distribution of Sir2. We identify Siz2 as the key SUMO ligase and show that multiple lysines in Sir2 are subject to this sumoylation activity. Mutating K215 alone counteracts the inhibitory effect of Siz2 on telomeric silencing. SUMO modification of Sir2 impairs interaction with Sir4 but not Net1 and, furthermore, SUMO modified Sir2 shows …