Abstract

We designed, developed and evaluated an Augmentative and Alternative Communication (AAC) system,AutVisComm,for children with autism that can run on smart phones and tablets. An iterative de-sign and development process was followed, where the prototypes were developed in close collaboration with the user group, and the usability testing was gradually expanded to larger groups. In the last evaluation stage described here, twenty-four children with autism used AutVisCommto learn to request the desired object. We measured their learning rates and correlated them with their behavior traits (as observed by their teachers) like joint attention, symbolic processing and imitation.We found that their ability for symbolic processing did not correlate with the learning rate, but their ability for joint attention did. This suggests that this system (and this class of AACs) helps to compensate for a lack of symbolic processing, but not for a lack of joint-attention mechanism.

Abstract

The task of detecting peri-papillary indicators associated with the glaucoma is challenging due to the high degree of intra and inter-image variations commonly seen in colour retinal images. The existing approaches based on direct modeling of the region of interest failto handle such image variations which compromises detection accuracy.In this paper, a novel detection strategy is proposed which exploits the saliency property associated with these indicators. The region of interest is modeled as a region substantially different from the adjacent image regions. This dissimilarity information is derived at the feature level, be-tween the target and its adjacent regions. Based on the proposed strategy,two novel methods are presented for the detection of peri-papillary atrophy and RNFL defect from colour retinal images. Two different datasets have been used to evaluate the performance of developed solutions. The obtained results are encouraging and establish the strength of the pro-posed strategy in handling high degree of image variations. The preliminary results and comparative evaluation with direct modeling strategy show viability of proposed strategy to be used in the glaucoma assessment task.

Abstract

Retinopathy of prematurity (ROP) is a vascular disease in premature infants. This is characterized by abnormal vessel growth and subsequent fibrosis in the peripheral retina. The prognosis of ROP relies on information on the presence of abnormal growth and their location. Diagnosis is based on a series of images obtained with a wide field of view camera (such as RetCam), to capture the complete retina. In this paper, we present a novel and efficient hierarchal mosaicing algorithm, for neonatal images of varying quality. We employ a vessel-based quality metric and exploit the knowledge of the retinal structure to automatically select a subset of images from a given set, to construct a good quality mosaic. Such mosaics can aid the assessment of ROP by providing a comprehensive and complete view of the entire retina. The hierarchal approach underlying the method makes it possible to complete the mosaicing task in close to real time. The proposed method has been tested on 14 sets of data with each set consisting of 6-35 retinal images acquired using RetCam and the generated mosaics are found to be of good quality as validated by a clinical expert.

Abstract

Accurate segmentation of the cup region from retinal images is needed to derive relevant measurements for glaucoma assessment. A novel, depth discontinuity (in the retinal surface)-based approach to estimate the cup boundary is proposed in this paper. The proposed approach shifts focus from the cup region used by existing approaches to cup boundary. The given set of images, acquired sequentially, are related via a relative motion model and the depth discontinuity at the cup boundary is determined from cues such as motion boundary and partial occlusion. The information encoded by these cues is used to approximate the cup boundary with a set of best-fitting circles. The final boundary is found by considering points on these circles at different sectors using a confidence measure. Four different kinds of data sets ranging from synthetic to real image pairs, covering different multiview scenarios, have been used to evaluate the proposed method. The proposed method was found to yield an error reduction of 16% for cup-to-disk vertical diameter ratio (CDR) and 13% for cup-to-disk area ratio (CAR) estimation, over an existing monocular image-based cup segmentation method. The error reduction increased to 33% in CDR and 18% in CAR with the addition of a third view (image) which indicates the potential of the proposed approach.

Abstract

Diabetic macular edema (DME) is an advanced symptom of diabetic retinopathy and can lead to irreversible vision loss. In this paper, a two-stage methodology for the detection and classification of DME severity from color fundus images is proposed. DME detection is carried out via a supervised learning approach using the normal fundus images. A feature extraction technique is introduced to capture the global characteristics of the fundus images and discriminate the normal from DME images. Disease severity is assessed using a rotational asymmetry metric by examining the symmetry of macular region. The performance of the proposed methodology and features are evaluated against several publicly available datasets. The detection performance has a sensitivity of 100% with specificity between 74% and 90%. Cases needing immediate referral are detected with a sensitivity of 100% and specificity of 97%. The severity classification accuracy is 81% for the moderate case and 100% for severe cases. These results establish the effectiveness of the proposed solution.

Abstract

Automatic retinal image analysis is emerging as an important screening tool for early detection of eye diseases. Glaucoma is one of the most common causes of blindness. The manual examination of optic disk (OD) is a standard procedure used for detecting glaucoma. In this paper, we present an automatic OD parameterization technique based on segmented OD and cup regions obtained from monocular retinal images. A novel OD segmentation method is proposed which integrates the local image information around each point of interest in multidimensional feature space to provide robustness against variations found in and around the OD region. We also propose a novel cup segmentation method which is based on anatomical evidence such as vessel bends at the cup boundary, considered relevant by glaucoma experts. Bends in a vessel are robustly detected using a region of support concept, which automatically selects the right scale for analysis. A multi-stage strategy is employed to derive a reliable subset of vessel bends calledr-bends followed by a local spline fitting to derive the desired cup boundary. The method has been evaluated on 138 images comprising 33 normal and 105 glaucomatous images against three glaucoma experts. The obtained segmentation results show consistency in handling various geometric and photometric variations found across the dataset. The estimation error of the method or vertical cup-to-disk diameter ratio is 0.09/0.08 (mean/standard deviation) while for cup-to-disk area ratio it is 0.12/0.10. Overall,the obtained qualitative and quantitative results show effective-ness in both segmentation and subsequent OD parameterization for glaucoma assessment.

Abstract

Pneumoconiosis, a lung disease caused by the inhalation of dust, is mainly diagnosed using chest radiographs. The effects of using contralateral symmetric (CS) information present in chest radiographs in the diagnosis of pneumoconiosis are studied using an eye tracking experimental study. The role of expertise and the influence of CS information on the performance of readers with different expertise level are also of interest. Experimental subjects ranging from novices & medical students to staff radiologists were presented with 17 double and 16 single lung images, and were asked to give profusion ratings for each lung zone. Eye movements and the time for their diagnosis were also recorded. Kruskal-Wallis test (χ2(6) = 13.38, p = .038), showed that the observer error (average sum of absolute differences) in double lung images differed significantly across the different expertise categories when considering all the participants. Wilcoxon-signed rank test indicated that the observer error was significantly higher for single-lung images (Z = 3.13, p < .001) than for the double-lung images for all the participants. Mann-Whitney test (U = 28, p = .038) showed that the differential error between single and double lung images is significantly higher in doctors [staff & residents] than in non-doctors [others]. Thus, Expertise & CS information plays a significant role in the diagnosis of pneumoconiosis. CS information helps in diagnosing pneumoconiosis by reducing the general tendency of giving less profusion ratings. Training and experience appear to play important roles in learning to use the CS information present in the chest radiographs.

Abstract

Segmentation in echo-cardiographic images is a difficult task due to the presence of speckle noise, low contrast and blurring. We present a novel method based on clustering performed in the feature space. A new feature-based image representation is proposed. It is obtained by computing a local feature descriptor at every pixel location. This descriptor is derived using the Radon-Transform to effectively characterise local image context. Next, an un-supervised clustering is performed in the feature space to segment regions in the image. The performance of the proposed method is tested on both synthetic and real images. A comparison against well established feature descriptors is carried out to demonstrate the strengths and applicability of the proposed representation. Overall, the results indicate promise in the strategy of doing segmentation of noisy data in image descriptor space.

Abstract

The most widely followed procedure for diagnosis and prognosis of dementia is structural neuro imaging of hippocampus by means of MR. Hippocampus segmentation is of wide interest as it enables quantitative assessment of the structure. In this paper, we propose an algorithm for hippocampus segmentation that is un-supervised and image driven. It is based on a hybrid approach which combines a coarse segmentation and surface evolution. A coarse solution is derived using region growing which is further refined using a modified version of the physics based water flow model (Liu and Nixon, 2007). The proposed method has been tested on a publicly available dataset. The performance of this method is assessed using Dice coefficient against the ground truth provided for 25 volume images. It is consistent across volumes and the average Dice values are comparable to a multi-atlas based method reported on a subset of the same dataset.

Abstract

Diabetic retinopathy is the leading cause of blindness in urban populations. Early diagnosis through regular screening and timely treatment has been shown to prevent visual loss and blindness. It is very difficult to cater to this vast set of diabetes patients, primarily because of high costs in reaching out to patients and a scarcity of skilled personnel. Telescreening offers a cost-effective solution to reach out to patients but is still inadequate due to an insufficient number of experts who serve the diabetes population. Developments toward fundus image analysis have shown promise in addressing the scarcity of skilled personnel for large-scale screening. This article aims at addressing the underlying issues in traditional telescreening to develop a solution that leverages the developments carried out in fundus image analysis.